ABSTRACT
Objective To probe into the psychological resilience and its influencing factor among parents of children with cancer.Methods A total of 125 parents were investigated by self-designed general information questionnaire,Connor-Davidson psychological resilience scale (CD-RISC),Chinese version of Parents' Perception Uncertainty in Illness Scale (PPUS),Social Support Rating Scale (SSRS),self-rating depression scale (SDS) and self-rating anxiety scale (SAS).Results The total score of psychological resilience was (54.86±12.88) and the illness uncertainty score was (91.52±14.66).The social support score was moderate with a total score of (39.86±7.99).The anxiety and depression among parents got a total score of (40.08±7.19) and (44.61±7.38) respectively.Psychological resilience was negatively correlated with illness uncertainty and depression,and was positively correlated with the social support.The depression,illness uncertainty,residence,children's age,clinical diagnosis entered into the multiple linear regression equation of psychological resilience,predicting 30.1％ of total variation in psychological resilience.Conclusions Social support,illness uncertainty and depression are the important factors which affect psychological resilience among parents of children with cancer.Nurses should assess the social support that parents receive,the level of depression and the disease feeling of the parents,and provide targeted interventions to relieve it,help to establish effective coping style and improve their psychological state.
ABSTRACT
Long-term potentiation (LTP) of synaptic transmission between the dendrites of the pyramidal cells of CA[ region and the Schaffer-commissu-ral pathway was induced with electric stimulation in the isolated hippocampal slices of rats.The effects of 3 convulsants,soman,kianic acid.and picroto-xin,on the induction of LTP in this region were observed.It was found that a short series of electric impulses could effectively induce LTP in most of the slices of the hippocampus and the amplitude of the population spikes showed a similar change as the field excitatory postsynaptic potential did in the rising phase.Picrotoxin could facilitate the induction of LTP when it evoked an epileptoform electric activity in the slices,kianic acid could also evoke an epileptoform activity but significantly blocked the induction of LTP,and soman could not evoke obvious epileptoform activity but blocked the induction of LTP.The above findings suggest that a short series of electric impulses can effectively induce LTP between the pyramidal cells and the Schaffer-commisural pathway in the CA1 region,the effects of epileptoform activity on the induction of LTP depends on the mechanism to evoke the epileptoform activity,and the effects of soman on the induction of field potential may involve the noncholi-nergic system in the synaptic connections.
ABSTRACT
The effects of intramuscular or intracerebroventricular injection of penta-gastrin(PG) on the action potential amplitude (APA) of the myocardial cells and the heart rate(HR) were studied. The results were as follows:1 ) Injection of 10?g/10?l of PG into one of the lateral ventricles of the ratfailed to produce any effect on APA or HR. When the dosage of PG was doubled(20?g/10?l), then HR could be slowed down significantly (P